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The microbiome is increasingly thought to be involved with cancer. A new multi-million dollar project led by researchers in the U.S. aims to investigate this link in colorectal cancer. & nbsp; Photo Credit: Getty Royalty Free.Getty
The microbiome is seemingly connected to every aspect of our health nowadays and now one of the world's biggest cancer charities, Cancer Research UK has dedicated up to $ 25 million to finding out it may be involved in colorectal cancer, the third most common cancer in the U.S.
There are many lifestyle factors that affect people's risk of developing colorectal cancer. Researchers are discovering that the effect of some of these factors on the microbiome, such as diet and obesity may play an important role in colorectal cancer development, progression and even response to cancer drugs.
The ambitious project involves 14 investigators spread between six different countries, but is led jointly by two U.S. researchers; Professor Matthew Meyerson of Dana-Faber Cancer Institute and Harvard Medical School and Professor Wendy Garrett from the Harvard T.H. Chan School of Public Health. Meyerson specializes in cancer genetics and Garrett's expertise is immunology and infectious diseases.
"The colon is the most densely populated microbial environment on the planet. Our tumors and cancers also harbor microbes that can contribute to whether we respond to a drug or not. There are wide opportunities for thinking about cancer, risk, development, treatment and cancer care through the lens of the microbiome," said Garrett.
One bacterial species called Helicobacter pylori has long been accepted to cause stomach cancer, but its link to colorectal cancer is uncertain, although there is growing evidence to suggest it is involved in some cases. There is also a lot of interest in bacteria found in the normal microbiome that are currently not thought to have any role in the disease.
"We and others have shown that the bacteria can promote colon cancer in a number of model systems and if you treat these infections it appears to be possible to limit the growth of these colon cancers. We do not really understand this in detail and there is enough evidence for this happening in people." said Meyerson.
The team will use a variety of experimental systems to investigate the possible relationship between bacteria and colorectal cancer including animal models and also organoids; tiny organs in a dish made from patients with colon cancer. The team will also look at the effect of current therapies for colorectal on the microbiome by collecting samples from patients receiving treatment.
"With new genomic technologies, we can map the microbiome in incredible detail, so now is the right time to be investigating this phenomenon of cancer. With this information, we hope to develop new microbiome-targeted therapies for colorectal cancer," said Meyerson.
This work is only a start and time will tell whether they have enough evidence that the microbiome is involved in colorectal cancer to try to change it to treat or even prevent the disease, but they are well set- up to do this work if early data is persuasive.
"First of all we have to care with any kind intervention. We have a number of clinical trialists involved in the study and a whole clinical trial network supporting this network and poised to jump in," said Garrett.
The ambitious five-year project will be jointly led by Dr. Matthew Meyerson and Dr. Wendy Garrett.Sam Ogden, Photographer Dana-Farber Cancer Institute
Cancer Research UK, which has historically funded researchers based in UK hospitals and universities is now branching out to fund 'The Grand Challenges', which link together traditionally separated research fields to come up with innovative solutions to some of the biggest challenges in cancer research.
"Cancer Research UK's Grand Challenge is set up differently from almost all other research funding, in that aims to bring together the brightest minds from a range of disciplines and from around the world to focus on specific challenges in cancer research. We received 134 applications from 41 different countries which were narrowed down to the final three projects for this year's funding round," said Iain Foulkes, PhD, Cancer Research UK's executive director of research and innovation.
New ways to tackle cancers caused by chronic inflammation and develop a deeper understanding of why cancers grow in some tissues but not in others. Both are also led by U.S.-based researchers with the funding provided for all three projects to around $ 75 million.
"Cancer is a global problem that needs a global solution. The quality of the applications has proven that the best science happens when the world's top scientists work in cooperation with each other," said Foulkes.
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The microbiome is increasingly thought to be involved with cancer. A new multi-million dollar project led by researchers in the U.S. aims to investigate this link in colorectal cancer. Photo Credit: Getty Royalty Free.Getty
Cancer Research UK has dedicated $ 25 million to finding out it can be involved in colorectal cancer, the third most common cancer in the theory US
There are many lifestyle factors that affect people's risk of developing colorectal cancer. Researchers are discovering that the effect of some of these factors on the microbiome, such as diet and obesity may play an important role in colorectal cancer development, progression and even response to cancer drugs.
The ambitious project involves 14 investigators spread between six different countries, but is led jointly by two U.S. researchers; Professor Matthew Meyerson of Dana-Faber Cancer Institute and Harvard Medical School and Professor Wendy Garrett from the Harvard T.H. Chan School of Public Health. Meyerson specializes in cancer genetics and Garrett's expertise is immunology and infectious diseases.
"The colon is the most densely populated microbial environment on the planet. Our tumors and cancers also harbor microbes that can contribute to whether we respond to a drug or not. There are wide opportunities for thinking about cancer, risk, development, treatment and cancer care through the lens of the microbiome, "said Garrett.
One bacterial species called Helicobacter pylori has long been accepted to cause stomach cancer, but its link to colorectal cancer is uncertain, although there is growing evidence to suggest it is involved in some cases. There is also a lot of interest in bacteria found in the normal microbiome that are currently not thought to have any role in the disease.
"We and others have shown that the bacteria can promote colon cancer in a number of model systems and if you treat these infections it appears to be possible to limit the growth of these colon cancers. There is enough evidence for this happening in people. " said Meyerson.
The team will use a variety of experimental systems to investigate the possible relationship between bacteria and colorectal cancer including animal models and also organoids; tiny organs in a dish made from patients with colon cancer. The team will also look at the effect of current therapies for colorectal on the microbiome by collecting samples from patients receiving treatment.
"With new genomic technologies, we can map the microbiome in incredible detail, so now is the right time to be investigating this phenomenon of cancer. With this information, we hope to develop new microbiome-targeted therapies for colorectal cancer, "said Meyerson.
This work is only a start and time will tell whether they have enough evidence that the microbiome is involved in colorectal cancer to try to change it to treat or even prevent the disease, but they are well set- up to do this work if early data is persuasive.
"We have many clinical trialists involved in the study and a whole clinical trial network supporting this network and poised to jump in," said Garrett.
The ambitious five-year project will be jointly led by Dr. Matthew Meyerson and Dr. Wendy Garrett.Sam Ogden, Photographer Dana-Farber Cancer Institute
Cancer Research UK, which has historically funded researchers based in UK hospitals and universities is now branching out to fund 'The Grand Challenges', which link together traditionally separated research fields to come up with innovative solutions to some of the biggest challenges in cancer research.
"Cancer Research UK's Grand Challenge is set up differently from almost all other research funding, in that aims to bring together the brightest minds from a range of disciplines and from around the world to focus on specific challenges in cancer research. We received 134 applications from 41 different countries which were narrowed down to the final three projects for this year's funding round, "said Iain Foulkes, PhD, Cancer Research UK's executive director of research and innovation.
New ways to tackle cancers caused by chronic inflammation and develop a deeper understanding of why cancers grow in some tissues but not in others. Both are also led by U.S.-based researchers with the funding provided for all three projects to around $ 75 million.
"Cancer is a global problem that needs a global solution. The quality of the applications has proven that the world's top scientists work in cooperation with each other, "said Foulkes.
