American researchers have developed a computational model that predicts the repairs of a specific DNA range after the cut of the Cas9 protein.
As this happens, it is possible to predict the possibility of higher order after 10th DNA repair work. This helped Scientists to correct harmful conversions in human bodies with Sirius without any use of matrix.
This is written by the chronicle.
The CRISPR-Cas9 genome editing system includes Cass 9 protein and a small seed (RNA). This basic kit, in fact, does not edit anything, it is replaced by a divergent gap in the genome. A third element is required to include the required order in this space – the template DNA, which contains the most sequence to be included in the genre. When used with this matrix, the adaptive cellular system will absorb the gap in the DNA and contain the necessary part through the system.
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If there is no matrix for maintenance (although this exists, because the human cells of the human body are functioning correctly), the other DNA. Repairs, especially the NOHOMOLOGICAL END CONNECTIONS SYSTEM (NHCH), Microhoglose (MMJ). After the operation of these systems, the position of the minor removal or inexpression remains in cuts. In most cases gene is dangerous. That is why CRISPR-Cas9's "basic set" may be easy to crash a jean, but it is not difficult to trouble.
The researchers of the Massachusetts Institute of Technology understood the absence of research systems. This is a model based on machine learning. This is a model that can predict the DNAN repairs through NHM, MMEJ. That means, remedied maintenance cases should be included in cases of at least 50% cases. There is a possibility that all 5-11% of RNA for man's genome ("exact -50") could predict the effect of such an accuracy. To develop an inDelphi model, nearly two thousand sites in the Sattarian DAS, after Casus Genome cut, experimental data was used.
Scientists have demonstrated its importance by creating this model. For this, they selected 14 from the list of the "correct 50" directors. The nature of a particular genetic velocity (especially a micrododied of a nucleotide) diseases. After the gap in this area, extra nucleotide will appear in inDelphi. In the case of CRISPR and repair system, the gene series has been restored in 60% of cases due to average micronutrients.
That is, some harmful mutations that lead to the development of diseases can be resolved with a higher capacity, with a CRISPR, with a matrix and maintenance. In total, 195 RNA guides were able to take the "50 correct" list for all such malicious nicknames. They proved to be true after more than 50% cut and repaired. For example, Hibroblasts of German-Pudlok syndrome patients could edit a mutation in the HPS1 gene. It causes pandemic, hemophilia, etc. They also experienced mutations in the ATP7A gene in mace patients cells.
All components of the nucleotide can also be modified without CRTPR-Cas based "basic editors" that can be corrected and genetically modified without having to use a matrix. For example, such a device was used by adult rats to determine how solar power of the faelectectonium was.
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