Friday , January 27 2023

China first claims children who make genetic variation



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Hong Kong A Chinese researcher who helped create the world's first genetically modified babies says: DNA of the two twins to combat human infectious viruses (HIV)

If it is true, it will be a deep leap in science and morality.

An American scientist said he had participated in the Chinese operation, but this type of Jean editing was banned in his country. Because changes in DNA can be transferred to future generations and other genes that are at risk.

Many traditional scientists believe it is very dangerous to test it, and some have condemned the Chinese report as a human experiment.

Shenzhen researcher Hei Jianiai said that the fetus had changed the embryo in seven pregnancies. A pregnancy has so far been reported. He does not intend to heal or prevent a traditional disease, but attempts to give some people a natural habit: a virus that causes HIV infections to prevent a future infection by a winning immune deficiency syndrome (AIDS).

He added that his parents were involved or refused to interview him. He did not tell where he worked and where he worked.

He did not have a free confirmation about claims and that other experts have not published a journal that examines it. One of the organizers of an International Conference on Tuesday said in Hong Kong, Hong Kong. He was speaking in an interview with the Associated Press.

"This is a big responsibility, it's a first and a model," he said. "The society will decide what to do next" about the allow or prohibit such science.

Some scientists were amazed at hearing this claim and strongly condemned it.

"Unexpected … an experiment for humans is not moral, moral or protection", Dr Mannar, editor of the genetics journal at Genetical Editing in the University of Pennsylvania. Kiran Murugesu said.

"It's too early," says Dr. Gregory of California's Script Translation Research Institute. "We are dealing with human activities, it's a big problem."

However, a well-known genetic scientist George Church of Harvard University defended the efforts of the HIV-affected genetic edition. He termed "a threat to public health".

"I think this can justify," said Churchill.

In recent years, the genes and body's beautiful DNA are readily available. This device, called CRISPR-cas9, makes it possible to work with DNA to either adopt a genetic adoption or to prevent someone from causing problems.

It was recently tested against adults to deal with deadly diseases and changes are limited to that person. The difference in sperm, ovules and embryos is different and changes can be made. Except laboratory research in the US is not allowed. Men prohibit cloning in China, but not particularly editing genes.

He talked about "JK" and studied at the Rice and Stanford Universities of the USA. Before opening a laboratory at the Science and Technology University in Shenzhen, he also has two genetics companies.

He was working with him and working with him after returning to China. Michael Dame, a professor of rice in Houston, was appointed as professor. He called a "small partnership" as part of the scientific advice of two companies.

Chinese researchers said that in laboratory mice, monkeys and human embryos have been corrected over the years.

In China, these infections are a major problem because he decided to check the gene of the embryo for HIV. He attempted to delete the genus CRR 5, which was created by a gateway of proteins that allowed HIV infections to enter a cell.

All males in the program were not infected with HIV. Not every woman did so. But the genital editing aim is not to prevent the risk of transmission. Parents have suppressed their infections with Aids AIDS HIV drugs, there are simpler ways to prevent them from affecting their genes.

Instead, it was an opportunity for a child to be protected from a similar HIV-infected couple.

A couple of couples have been appointed by the Aids Advocacy Group from Beijing. The name suggests that its leader, known in pseudonym "Bai Hua", is infected with HIV infected or lost their job or getting medical care if it is revealed by their infections.

That's how the work was done:

The fertilization of the gene or laboratory plate occurred during IVF. First, the sperm is "washed" to separate the sperm from the first sperm, the liquid of HIV. One semen is one ovary for creating an embryo. Then the Jean editing tool was added.

When the embryos were 3 to 5 days old, some cells were removed and their editing was checked. Couples can decide whether or not to use edited embryos for pregnancy efforts. 16 of the 22 embryos were published. Two embryos were used on six embryos before twin miscarriage.

Evidence suggests that copies of both genes and twin copies for a single child have no evidence of damage to other genes. Those with a copy of jeans still suffer from HIV, and some limited research suggests that their health will be reduced gradually.

When scientists examined the materials given to the Pandya, they said that these experiments did not work and they would be damaged.

They showed that the edition was rare and many twins would be the mosaic of many variable cells.

Only some cells have been altered because it could cause HIV infection.

The church also questioned Mussunool's decision to use an embryo for pregnancy in pregnancy. Because Chinese researchers knew the copies of the required copies did not change.

"There is nothing to protect the HIV infected victim in that child, yet he exposes the child for all the unknown vulnerabilities," said Mussun.

The use of the embryo indicates that the main emphasis on researchers is "examining the problem rather than avoiding this disease," said Churchill.

Common CCR5 genes face the risk of facing diseases such as viruses such as the West Nile. There are a number of ways to prevent HIV infection, according to Mussu. If that happens, it is very irresponsible.

There are also questions about what he proposed. He made a formal announcement on 8 November, following the Chinese Registry of Clinical Trials.

It is not clear if fully understood the partners' motives, potential risks and benefits. For instance, consent plans are called the project "Development of HIV / AIDS Vaccines".

When potential partners give their consent, they will be ready to understand the risks, said rice scientist Dee.

He worked in vaccine research in Rice. He thinks that the gene's edition is a vaccine.

"One layman describes it," he said.

Both men who do not have experience in clinical trials in physics are also physicists.

The Chinese scientist said that he personally made goals, but the participants said that they never tried to edit the embryo's gene and that it was at stake. He said that any child would be given insurance coverage on the basis of the scheme. Adults once complete a medical follow up until the child is 18 years or older.

Other pregnancy events, analyzing its analysis and coming up to the field experts, but "first" conceived that the partners did not get the chance to prove that they had been added once, and he agreed. Free fertility treatment was part of their treatment.

He is recognized for his project at Shenzhen Harmony's Women's and Children's Hospital, one of the four crazy hospitals for research into his research.

Some employees in certain hospitals remained in the dark about the nature of the investigation, which, according to them and Deim, did so to prevent some partners' HIV infection.

"We believe it's moral," said Lin Chittong, a manager of the Harmonique.

He said he knew any medical authority working in the sample of HIV. The fetus pierced the editing tool in the lab's lab and pierced some of the pregnancy tests.

Participants in the study were not moralists, but he said, "They are very informative about what they are doing wrong, because that's their life."

"I think this will help the family and their children," he said. If unnecessary side effects or damage occur, "I feel the same pain, that's my responsibility."

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